2 mV in 36 subjects (0.3%). This finding was associated with an increased risk of cardiac death (p < 0.001). Watanabe et al. (20) found ER in 63% of 37 patients with short QT and associated sudden death (SQT syndrome). Ghosh et al. (21) reported that in 2 patients with aborted sudden death, ER was Raf targets associated with large local dispersion of repolarization. In a recent prospective study of 2,063 subjects between 35 and 74 years of age, prevalence of ER was 18.5%, and ER was associated with increased cardiovascular mortality (22). In publications in which the ER pattern (mostly in leads III, aVF, and V4 to V6) is identified by an arrow (19, 20?and?22), the 12-lead ECGs were recorded at the speed of 25 mm/s. When the figures were magnified, it was possible to see that the arrows pointed either at a slow descent of the R-wave toward baseline (reminiscent of poor frequency response of the recorder), or at notches before or after the approach of R descent to the baseline. In 1 case, the terminal deflection resembled that of an incomplete right bundle branch block. Unfortunately, the deflections marked as ER in the aforementioned studies were not synchronized in several leads, not recorded at higher paper speeds, and not examined by body surface mapping or vectorcardiography. Thus, it is not possible to know whether the alleged ER is indeed an abnormality of repolarization. Wellens in his editorial comment (23) on the study of Haissaguerre et al. (18) questioned ?????whether the described abnormality at the end of QRS complex is indeed early repolarization, or rather delayed activation of the inferolateral wall.?? GDC-0199 solubility dmso The origin Torin-1 of the terminal QRS portion was debated in subjects with the Brugada syndrome (24). The electrocardiographic terminology stemming from the end of the 19th and the beginning of the 20th century has undergone few modifications when scrutinized by a succession of task forces appointed by the ACC or the AHA from 1978 (25) onward. The terminology, including ST-segment elevation, was recommended by the most recent task force of the AHA/ACC/HRS, published in 2009 ( 14). In our opinion, the established ECG terminology is sufficient to define clearly and accurately all normal and abnormal ECG patterns, and therefore terms other than the existing electrocardiographic nomenclature, such as J-wave syndrome and early repolarization are superfluous and confusing. The J-wave was described originally in the setting of deep hypothermia, where it was often a precursor of ventricular fibrillation. The J-wave is very seldom encountered under other circumstances. The J-point exists in all ECGs but does not need to be singled out in the ECG reports describing ST-segment deviations because it is a component of the ST segment. The terms early and late repolarization are synonymous with phases 2 and 3 of the transmembrane action potential. In the ECG, they correspond to ST segment and T-wave.